Hapacol 150 Flu

Barcode: 8935206094923


Paracetamol................................. 150 mg

Chlorpheniramine maleate............. 1 mg

Excipients.q.s.............................. 1 sachet

(Mannitol, anhydrous citric acid, aspartame, PVP K30, quinoline color, sodium hydrocarbonate, refined sugar, orange-flavored powder).


Effervescent powder.


Box of 24 sachets x 1.5 g.


Hapacol 150 Flu is analgesic, antipyretic, and anti-allergic combined from two active ingredients:

Paracetamol is priorly used in treatment of fever and pains in children. Paracetamol has action on the hypothalamic heat-regulating center causing hypothermia, increase in thermolysis due to vasodilation and peripheral hypervolemia; this relieves the body temperature in fever patients, but rarely reducing in normal cases. Paracetamol produces analgesia by elevation of the pain threshold.

Chlorpheniramine maleate is histamine H1-receptor antagonists; therefore, it reduces the secretion of nose mucus and mucilage from upper respiratory tract.

The combination of Paracetamol and Chlorpheniramine in Hapacol 150 Flu quickly reduces symptoms such as fever, headache, coryza. These symptoms often occur when suffering from cold or rhinitis, sinusitis.

Hapacol 150 Flu is prepared in the dosage form of effervescent powder with flavor and sweet taste, dissolved in water before use; therefore, it is ideal for children. The drug is quickly and mostly absorbed by the gastrointestinal tract.


Treatment of cold, fever, stuffiness, coryza, rhinitis, catarrhal mucitis, sinusitis, pains and aches e.g headache, myalgia, and osteoarticular pains due to flu or allergy to weather.


Hypersensitivity to any components of the drug.

In cases of glucose-6-phosphate dehydrogenase deficiency; impaired hepatic function.

Patients with anemia, cardiopathy, pneumopathy, renopathy.

Patients with narrow-angle glaucoma, acute course of asthma, protatauxe.

Pregnant women and breast-feeding mothers.

Newborn babies and premature babies.


Observe renal function in case of prolonged use or renal impairment.

Sleeplessness may occur; therefore, be careful when driving or operating machinery.

Patients on sodium-free diets are warned.


In concerning with paracetamol: Concurrent use of Paracetamol and anticoagulant has been reported to enhance the effect of anticoagulant.

In concerning with Chlorpheniramine: Do not use concurrently chlorpheniramine and alcoholics, narcotic tranquillizers, phenytoin.


In concerning with paracetamol:

Uncommonly: rash, nausea, neutrophilopenia, pancytopenia, hypoleukemia, anemia, renopathy, nephrotoxicity due to long-time abuse.

Rarely: hypersensitive reactions.

In concerning with chlorpheniramine: dryness of month, dysaptation, urinary retention, sweating, and drowsiness.

Inform the physician about any adverse effects occur during the treatment.


Paracetamol overdosage is due to a single-dose or repeated large doses ingestion (7.5 - 10 g daily for 1 - 2 days), or long-time ingestion. In acute paracetamol overdosage, dose-dependent, potentially fatal hepatic necrosis is the most serious adverse effect.

Symptoms of paracetamol overdose include nausea, vomiting, colic, cyanosis on skin, mucosa, nails.

Treatment of overdosage:

In the event of severe paracetamol overdose, full supportive measures should also be instituted. Gastric lavage should be carried out especially if the overdose was taken within the previous 4 hours.

The main detoxication therapy is use of sulfhydryl compound. N-acetylcysteine gives its effect followed by oral route or an intravenous infusion. N-acetylcysteine should be administered as soon as possible, preferably within 36 hours of overdosage.

N-acetylcysteine is more effective if administered within 10 hours of overdosage. It can be diluted with water or alcohol-free drinks to a 5% solution and orally taken within 1 hour. Oral N-acetylcysteine is given as a 140 mg/kg body-weight initial dose followed by 70 mg/kg body-weight every four hours for 17 more doses.

Methionin, activated charcoal and/or salt cathartic are also advised to treat overdose.

Symptoms of chlorpheniramine overdosage include sedation, psychonosema, seizure, apnea, convulsions, acetylcholine anti-secretory effect.

Treatment: Emptying the stomach or inducing emesis by ipecacuanha syrup, then using activated charcoal or cathartic to reduce the absorption. An active treatment should be taken in patients with hypotension and cardiataxia. Convulsions may be treated with diazepam or phenytoin by intravenous injection.


Dissolve the effervescent powder in some fresh water (ideal for children) until ending effervescence. 

Children 1 – 2 years of age: 1 sachet x 2 times/ day

Children 2 – 3 years of age: 1 sachet x 3 – 4 times/ day.

Taken once every 4 - 6 hrs, not more than 5 times/ day.

Children aged 2 - 3 years: oral dose of 1 sachet.

Or as directed by the physician.

Notes: A long-term treatment should not be applied in children if there is no physician's advice, consult a physician if:

- New symptoms occur.

- Fever gets worse (39.50C) and lasts for more than 3 days.

- Pain gets worse or lasts for more than 5 days.

Read the directions carefully before use.

Consult the physician for more information.

Shelf-life: 24 months from the manufacturing date.

Storage conditions: Store in dry places, not exceeding 300C.

Specifications: Manufacturer's.


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