Acezin DHG

Barcode: 8935206003697

Alimemazine tartrate .................................................................................. 5 mg
Excipients q.s......................................................................................... 1 tablet
(Aerosil, wheat starch, lactose, talc, magnesium stearate, HPMC, PVA, PEG 6000,
kollidon VA 64, titanium dioxide, erythrosine lake color, FD & C Blue No 1 Alum).
DOSAGE FORM: Film coated tablets.
PRESENTATION: Box of 2 blisters x 25 tablets. Box of 10 blisters x 10 tablets. Bottle of 300 tablets.
ACTIONS: Alimemazine is a phenothiazine derivative which is a potent antihistamine and antiserotonin. Alimemazine also acts as sedative, antitussive, antiemetic. Alimemazine is competitive with histamine at the histamine H1-receptors, thus it is resistant to histamine H1, and antagonistic with most of pharmacological actions of histamine including urticaria, pruritus. Alimemazine is a sedative due to histamine N-methyltransferase enzyme inhibition and due to blocking central receptors secreting histamine and concomitantly acting on other receptors, especially serotoninergic receptor. Besides, Alimemazine is antiemetic by a direct effect on the chemical sensitive central area of spinal cord, maybe by blocking dopaminergic receptors at this area. Alimemazine is rapidly absorbed by the gastrointestinal tract. After taking drug for 15 - 20 minutes, the drug’s effect lasts for 6 - 8 hours. Elimination half-life is 3.5 - 4 hrs; 20 - 30% bound to plasma protein. Alimemazine is excreted via kidney under sulfoxide metabolites (70 - 80% after 48 hours).
INDICATIONS: Symptomatic treatment of various cases: Respiratory allergies (rhinitis, sneezing, coryza) and skin rashes (urticaria, pruritus). Dry cough (due to allergy or irritation).
Alimemazine tartrate can be used as a substitute agent for benzodiazepine in short-term treatment of insomnia.
CONTRAINDICATIONS: Hypersensitivity to alimemazine or phenothiazine derivatives. Children aged < 2 years. Impaired hepatic, renal function, epilepsy, Parkinson's disease, hypothyroidism, myasthenia, prostatauxe. Known granulocytopenia, closed-angle glaucoma.
PRECAUTIONS: Caution should be taken in the elderly especially in so hot and cold weather (a risk of hypothermia or hyperthermia); the elderly who is easy to suffer from orthostatic hypotension. Patients with angiocardiophathy.
PREGNANCY AND LACTATION: The drug is not indicated in pregnant women and nursing mothers.
VEHICLE DRIVERS AND MACHINERY OPERATORS: The drug should be used with caution in vehicle drivers and machinery operators because the drug has sedative effect and induces drowsiness.
INTERACTIONS: Alcohol may increase the sedation effect of alimemazine, so alcohol should be avoided during the therapy.
Concomitant administration of alimemazine and barbituric soporific and other sedatives is reported to increase the effect of central nervous system inhibition, respiratory depression of alimemazine. Concurrent administration with other anticholinergics may enhance anticholinergic effect of alimemazine. Antacids, Parkinson-treatment drugs, lithium prevent the absorption of alimemazine.
ADVERSE EFFECTS: Drowsiness, headache, lassitude, dizziness, dryness of mouth, increased viscidity of bronchial secretion, optical accomodation disorders, constipation, urinary retention.
Rarely: agranulocytosis, hypoleukemia, hypotention, tachycardia, jaundice hepatitis caused by cholestatic, extrapyramidal symptom, Parkinson tremor, anxiety, acute dystonia, decrease in convulsant threshold in epilepsy.
Inform your physician about any adverse effects occur during the treatment.
OVERDOSAGE: Symptoms of overdosage includes drowsiness or loss of consciousness, hypotension, tachycardia, ECG changes, ventricular arrhythmias and hypothermia. Extra-pyramidal reactions may occur.
Treatment of overdosage: Gastric lavage should be carried out especially if the overdose was taken within the previous 6 hours. Pharmacological induction of emesis is unlikely to be of any use. Activated charcoal should be given. There is no specific antidote. Treatment should be supportive in cases of cardiovascular collapse, arrhythmias, severe central nervous inhibition.
DOSAGE & ADMINISTRATION: Short-term treatment of.
* Allergy and cough: Adults: oral dose of 1 - 2 tablets x 2 - 4 times daily.
           Children aged > 2 years: oral dose of 0.5 -1 mg/ kg body-weight daily, in divided doses.
* Insomnia: Adults: oral dose of 1 - 4 tablets before bedtime.
              Children aged > 2 years: oral dose of 0.25 - 0.5 mg / kg body-weight daily before bedtime.
Or as directed by the physician.
Read the directions carefully before use.
Consult the physician for more information.
Shelf-life: 36 months from the manufacturing date.
Storage conditions: store in dry places, not exceeding 30oC, protect from light.
Specifications: Manufacturer's.


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