DAVITA BONE SUGAR FREE

COMPOSITION:

Calcium carbonate ………………………………….. 1500 mg

(Equivalent to 600 mg of calcium)

Vitamin D3 ………………………………. 400 IU

Excipients q.s …………………………… 1 tablet

(Anhydrous citric acid, aspartame, sodium saccharin, sunset yellow, PEG 6000, sodium benzoate, orange-flavored powder, effersoda, PVP K30).

DOSAGE FORM: Effervescent tablets.

PRESENTATION: Box of 1 tube x 10 effervescent tablets.

ACTIONS:

Davita Bone Sugar Free including Calcium and Vitamin D is used to prevent osteoporosis. Calcium particularly plays an important role in bone - teeth formation, hematopexis, signal transmission activities of cells, and muscular contraction. Calcium is the most abundant mineral in the human body. Ninety nine percent of calcium is stored in bones and teeth. The sufficient absorption of calcium restrains risks of osteoporosis. Vitamin D is a pre-hormone, makes metabolites as hormones. The main function of vitamin D is to increase calcium absorption in the intestine and carry out bone formation and mineralization normally.

Davita Bone Sugar Free is prepared in the dosage form of saccharose-free effervescent tablets and meets the demand of prevention of osteoporosis. Specially, it is safe for diabetic patients and individuals going on a diet.

INDICATIONS:

Prevention and treatment of osteoporosis in those associated with getting a high risk: women aged > 30 years, the elderly, diabetics, dieter, alcoholics, and smokers.

Prevention and treatment of osteomalacia.

Supplement of calcium and vitamin D for pregnant and breast-feeding women, children and adolescents during the growth phase.

CONTRAINDICATIONS:

Hypersensitivity to any components of the drug. Hypercalcaemia. Severe renal impairment, nephrolith.

Do not use concurrently Davita Bone Sugar Free with other preparations containing calcium and vitamin D

PRECAUTIONS:

Use with caution in individuals receiving a salt-free diet. Mild or moderate renal impairment or a history of renal calculus.

Hypoparathyroidism; impaired renal function; heart disease; atherosclerosis, respiratory failure or blood acidosis.

PREGNANCY AND LACTATION:

Davita Bone Sugar Free can be used to supplement calcium and vitamin D according to the daily demand. Vitamin D should not be used in excess of the recommended dose of vitamin D (400 IU) daily.

VEHICLE DRIVERS AND MACHINERY OPERATORS:

The drug does not affect the possibility of driving vehicles and operating machinery.

INTERACTIONS:

Tetracycline, flour, estramustine, biphosphonate, phenytoin, quinolone prevent calcium absorption; therefore, do not take Davita Bone Sugar Free within 3 hours before or after using the above drugs.

Thiazide diuretics reduce the elimination of calciuria, induce risk of hypercalcaemia. Concurrent use of high-dose calcium and digitalis increases risk of cardiataxia.

ADVERSE EFFECTS:

Gastrointestinal disturbances (constipation, indigestion, and diarrhoea) have been rarely reported.

Inform your physician about any adverse effects occur during the treatment.

OVERDOSAGE:

Blood calcium concentration of over 2.6 mmol/ l (10.5 mg/ 100 ml) is considered hypercalcaemia.

Patients with no clinical manifestations and normal renal function just need to discontinue the calcium-containing drugs.

Blood calcium concentration of over 2.9 mmol/ l (120 mg/ 100 ml) must apply the following methods: Perfusion by intravenous infusion with sodium chloride 0.9%; compulsory diuretic by furosemide or ethacrynic acid. Observe the blood potassium and magnesium concentrations and replace the blood early to prevent complications during the therapy. Monitor the cardiogram and possibly use beta-blockers to prevent severe cardiataxia. Determine the blood calcium level at the given time in order to orient the therapy method.

DOSAGE & ADMINISTRATION:

Davita Bone Sugar Free is used for diabetic patients and individuals being a diet.

Dissolve one Davita Bone Sugar Free effervescent tablet in a glass of water (about 200 ml) to get an orange-flavored drink. Davita Bone Sugar Free should be used at any time of the day and taken after meals.

For prevention of osteoporosis, osteomalacia or supplement of daily calcium demand, one tablet a day should be recommended.

For treatment of calcium deficiency, osteoporosis, and osteomalacia, one tablet twice a day is advised.

Or as directed by the physician.

Read the directions carefully before use.

Consult the physician for more information.

Shelf-life: 36 months from the manufacturing date.

Storage conditions: Store in dry places, not exceeding 30⁰C, protect from light.

Specifications: Manufacturer’s.