Ferrous fumarate .........................162 mg
(Equivalent to 53.25 mg of elemental iron)
Folic acid ................................... 0.75 mg
Vitamin B12 ...............................7.5 mcg
Excipients q.s........................... 1 capsule
Soft capsule.
Box of 3 blisters x 10 soft capsules.
ATC code: B03AE01
Iron is necessary for the formation of haemoglobin, myoglobin and cytochrome C respiratory enzymes.
Folic acid is an indispensable element in the synthesis of nucleoprotein and normal erythropoiesis. A deficiency of folic acid causes megaloblastic anaemia (like anemia due to vitamin B12 deficiency).
Vitamin B12 has a hematopoietic effect. When vitamin B12 levels are not enough, the function of several types of folic acid has been reported to decline.
Iron is normally absorbed from the duodenum and jejunum. Iron is stored in the body in two forms: ferritin and hemosiderin. About 90% of iron entered into the body is excreted in the feces.
Folic acid is absorbed, mainly from the proximal part of the small intestine. The drug is mainly stored in the liver and is actively concentrated in the cerebrospinal fluid. Every day around 4 - 5 mcg of folic acid is excreted in urine.
Vitamin B12 is absorbed through the intestine, mainly in the ileum. After absorption, vitamin B12 links transcobalamin II and is rapidly removed from plasma to distribute priority in the liver parenchyma. The liver is a store of vitamin B12 to other tissues. Vitamin B12 is excreted in the bile.
Caution should be exercised in patients who may suffer from folate-dependent tumors, allergy to soybeans, peanuts, ponceau, fructose intolerance.
Pregnancy and lactation: Bofit F can be used during pregnancy and lactation.
Effects on works: No studies have been shown on drivers, machinery users, workers at height and other cases.
Concurrent use of the drug and sulfasalazine, anticonvulsants, cotrimoxazole should be taken with caution.
Avoid concomitant use of the drug with quinolone, tetracycline antibiotics; penicillamine, carbidopa/levodopa, methyldopa, parathyroid hormones, zinc salts, tea and antacids such as calcium carbonate, sodium carbonate, magnesium trisilicate.
The side effects related to the gastrointestinal tract: abdominal pain, nausea, vomiting, constipation.
Caution should be exercised in patients who may suffer from folate-dependent tumors, allergy to soybeans, peanuts, ponceau, fructose intolerance.
Pregnancy and lactation: Bofit F can be used during pregnancy and lactation.
Effects on works: No studies have been shown on drivers, machinery users, workers at height and other cases. OVERDOSE:
Toxic dose may cause moderate poisoning at a dose of below 30 mg of Fe2+ per kg body-weight and severe poisoning at dose of above 60 mg of Fe2+ per kg body-weight. Fatal dose may be from 80 to 250 mg of Fe2+ per kg body-weight. The minimum fatal dose in children is reported 650 mg of Fe2+.
Symptoms: abdominal pain, nausea, vomiting, bleeding diarrhea, dehydration, acidosis, doze-accompanied shock. There are periods that seem recoverable with no symptoms, but after 6 to 24 hours the symptoms reappear including hemopexis and cardiovascular collapse. Some manifestations including high fever, hypoglycemia, liver poisoning, renal impairment, convulsions, and coma are reported.
Management: Firstly, gastric lavage with milk (or carbonate solution) is immediately employed, then pumping deferoxamine solution. Blood pressure is, if necessary, increased by dopamine. Dialysis is indicated in case of renal impairment. Adjustment of acid-base and electrolyte equilibrium and rehydration are advised.
Read the directions carefully before use.
For more information, please consult a physician.
Store in dry places, not exceeding 300C, protect from light.
Treatment of iron deficiency anemia in pregnant women, children, adolescents, or adults with internal bleeding such as intestinal bleeding or colon cancer and bleeding ulcers, and in patient taking hemodialysis or gastric surgery.
Prophylaxis of iron and folic acid deficiency in children, young women during the menstrual period, women in reproductive age with blood loss and pregnant women who need more iron to increase blood volume and fetus development.
A history of hypersensitivity to any component of the medication.
Malignancy; haemochromatosis: hemochromatosis, haemosiderosis, and hemolytic anemia.
1 capsule once to twice daily after meals.
Or as directed by the physician.
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