Active ingredient: Zinc gluconate ........ 70 mg
Excipients: q.s ……………………………… 1 tablet
Film coated tablet.
Product description: A white to off-white, round, film coated tablet, scored on one side and a pattern on the other side, undamaged edges.
Box of 10 blisters x 10 film coated tablets.
Pharmacotherapeutic group: Mineral supplement, ATC code: A12CB02.
Zinc is an essential trace element for humans. Overall, an adult body contains around 2 - 3 g of zinc. The daily requirement is approximately 15 mg. In blood, about 90% are bound in erythrocytes (mainly in carbonic anhydrase) or leukocytes and only 10% in serum (0.1% of total zinc), mainly to albumin, less to alpha-2-macroglobulin and transferrin.
Zinc plays an essential role as a structural, catalytic or regulatory component of enzymes, e.g., in alkaline phosphatase, various dehydrogenases, thymidine kinases, carboxypeptidases, DNA and RNA polymerases and together with copper in superoxide dismutase. In the pancreas, zinc is required as a complexing agent for insulin and glucagon. Zinc is required for gonadal maturation, testicular steroidogenesis, and fertility. In cellular and humoral immune responses, for example, the presence of zinc is prerequisite for mitogenic stimulation of immune cells. The function of T lymphocytes, macrophages and granulocytes is also dependent on zinc.
The biochemical functions of zinc are particularly evident when there is a zinc deficiency. The rapidly growing tissues are most severely affected (e.g., sperm, embryos, fetal cells, immunocompetent cells, connective tissue in wound granulation). Zinc serves primarily to stabilize DNA, RNA and protein.
About 10 - 40% of zinc contained in food is absorbed from the intestine. The absorption occurs mainly in the duodenum and the upper part of the small intestine. However, the amount absorbed is variable and depends on many factors. Therefore, a protein-rich diet increases zinc absorption while phytic acid found in beans and grains inhibits zinc absorption by forming insoluble and unabsorbed complexes. The zinc absorption can also be inhibited by cadmium, copper, calcium or iron.
Zinc is mainly eliminated in the feces; renal elimination is low (0.3 - 0.6 mg daily).
Zinc concentrations in tissues are variable. Radiolabeled zinc appears 40% in the liver and decreased to 25% in 5 days. Some factors, particularly hormones, affect hepatic zinc levels. In the liver, as in other tissues, zinc is bound to metallothionein. The highest concentrations of zinc are found in bones, skin, prostate, muscle, and sperm.
The medicine has no influence on the ability to drive vehicles and use machines.
In the therapeutic dose range, there are no restrictions to these subjects.
If zinc and iron, copper or calcium salts are administered simultaneously, the absorption of zinc may be reduced.
The administration of chelating agents such as D-penicillamine, dimercaptopropane sulfonic acid (DMPS) or edetic acid (EDTA) can reduce the absorption of zinc or enhance its excretion.
Zinc can reduce the absorption of copper, iron and calcium.
The efficacy of antibiotics such as tetracyclines, ciprofloxacin and other quinolones is reduced by concurrent administration with zinc. Therefore, the interval between oral doses of zinc and these preparations should be at least 2 hours.
Ingredients in plant-based foods (grains, beans, nuts) reduce the absorption of zinc.
Very rarely (<1/10,000): nausea or vomiting. In these cases, zinc should be taken with meals; however, if possible, zinc taken concurrently with plant-based foods should not be recommended (see section Interactions).
Please inform your doctor of all undesirable effects upon drug administration.
Only when the oral dose is many times higher than the therapeutic dose, overdose can occur. Symptoms of overdose include metallic taste on tongue, headache, diarrhea, and vomiting. These symptoms disappear quickly after the medicine is discontinued.
Store in dry places, not exceeding 30oC, protect from light.
In case of long-term use of zinc, zinc and copper concentrations should be monitored by laboratory diagnostics.
Excipients
This medicinal product contains less than 1 mmol sodium (23 mg) per tablet, that is to say essential "sodium-free".
The proven zinc deficiency.
Therapy with penicillamine and other chelating agents
Hypersensitivity to the active ingredient or to any of the excipients of the medicinal product.
Posology: 1 - 2 tablets daily.
Method of administration: Since the absorption can be affected by food, the tablets should be taken with a glass of water approximately 1 hour before meals.
Duration of application: The duration of use depends on needs and the success of the treatment.
Children and adolescents: No data is available.
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