Amoxicillin (as amoxicillin trihydrate) 250 mg
Excipients q.s ................................... 1 capsule
Hard capsules (grey - ivory yellow)
Box of 10 blisters x 10 capsules.
Hagimox 250 Caps contains the active ingredient amoxicillin which is a penicillin antibiotic. Amoxicillin is an aminopenicillin, stable in gastric acid, and has a broader spectrum of activity than benzylpenicillin, particularly in Gram-negative bacteria. The bactericidal effect of amoxicillin is by interfering with the biosynthesis of the bacterial cell wall mucopeptide. Amoxicillin is bactericidal for both Gram-positive and Gram-negative organisms: Streptococcus pneumoniae, non-penicillinase-producing Staphylococcus, H. influenzae, Diplococcus pneumoniae, N. gonorrheae, E.coli and Proteus mirabilis. Amoxicillin is not active against penicillinase-producing strains, especially methicillin-resistant Staphylococcus spp., all strains of Pseudomonas and most of Klebsiella and Enterobacter strains. Amoxicillin has been reported to be more active in vitro than ampicillin against Enterococcus faecalis and Salmonella spp. but less active against Shigella spp. The spectrum of activity of amoxicillin may be extended by the concomitant use of sulbactam and clavulanic acid. Amoxicillin-clavulanic acid (16.8%) is reported to be resistant to E. coli.
Amoxicillin is stable in the presence of gastric acid. The absorption is not affected by food, it is more rapidly and completely absorbed than ampicillin when given by mouth. Amoxicillin is widely distributed in body tissues and fluids, except for brain tissue and cerebrospinal fluid, but Amoxicillin is readily diffused when meninges are inflamed. The half-life of amoxicillin is 61.3 minutes and it may be longer in neonates and the elderly. In renal impairment patients, the half-life is approximately 7 - 20 hrs. About 60% of an oral dose of amoxicillin is excreted unchanged in the urine within 6 – 8 hours. Probenecid retards renal excretion. High concentrations have been reported in bile; some may be excreted in the faeces.
The effect of amoxicillin on the ability to drive vehicles and operate machinery is rarely reported.
Renal and hepatic functions should be periodically observed in case of long-term administration. A severe hypersensitive reaction may occur in patients with a history of allergy to penicillin or other allergens, so their history of allergy should be observed carefully before they are administered the drug.
In case the allergic reaction e.g. erythema, Quincke's oedema, anaphylactic shock, or Stevens-Johnson syndrome occurs, stop using amoxicillin, give first-aid treatment with adrenaline, supply oxygen, intravenous injection of corticosteroid, inner tracheal cannula and never use penicillin or cephalosporin anymore.
The safety of amoxicillin in pregnant women has not been determined; therefore, just use in really required cases. However, the harms of Amoxicillin in foetus have not been proven.
Amoxicillin has been shown to be excreted in human milk. Caution should be exercised when amoxicillin is administered to a nursing woman.
Nifedipine increases the absorption of amoxicillin.
Allopurinol has been reported to enhance risks of allergic reactions of amoxicillin.
Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use of amoxicillin and probenecid may result in increased blood levels of amoxicillin.
There is an antagonism between amoxicillin and bacteriostatic substances such as chloramphenicol, tetracyclines.
Common: skin rash (3 - 10%), slowly appears after 7 days of treatment.
Uncommon: nausea, vomiting, diarrhea. Erythema, lumps, urticaria, particularly Stevens-Johnson's syndrome.
Rare: mildly elevated SGOT, excitation, writhing, anxiety, insomnia, confusion, and change in mood and/or dizziness. Anaemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, hypoleukemia, granulocytopenia.
Inform your physician about any adverse effects occur during the treatment.
No documents have been reported.
Store in dry places, not exceeding 300C, protect from light.
36 months from the manufacturing date.
Treatment of infections:
Infections of the upper respiratory tract.
Infections of the lower respiratory tract due to Streptococcus spp., S. pneumoniae, non-penicillinase-producing Staphylococcus and H. influenzae.
Uncomplicated genitourinary tract infections, gonorrhoea, biliary tract infection.
Skin and skin structure infections due to Streptococcus spp., Staphylococcus spp., E. coli sensitive to amoxicillin.
A known history of hypersensitivity to any penicillins.
The drug can be taken before or after meals.
Adults and children > 10 years of age: 500 mg (2 capsules) x 3 times daily.
Children aged 5 - 10 years: 250 mg (1 capsule) x 3 times daily.
High dosage therapy, single dosage or short course therapy is used in cases:
Dental abscess: 3 g dose with 8 hours between the doses. Uncomplicated urinary tract infection: 3 g dose with 10 - 12 hours between the doses.
For prophylaxis of endocarditis in susceptible people, a single dose of 3 g is taken before tooth extraction.
High dosage therapy of 3 g twice daily is recommended in patients with severe or recurrent purulent infections of the respiratory tract.
If needed, 750 mg twice a day for two days may be used in children aged 3 to 10 years with otitis media.
For patients suffering from renal impairment:
Cl creatinine < 10 ml/ min: 500 mg/ 24 hrs.
Cl creatinine > 10 ml/ min: 500 mg/ 12 hrs.
Or as directed by the physician.
Read the directions carefully before use.
Consult the physician for more information.
This drug is for prescriptions only.
Register an account - receive thousands of information
You will be one of the first to receive information, news, recruitment news... from Hau Giang Pharmaceutical as soon as possible. Register today to enjoy thousands of incentives from Hau Giang Pharmaceutical.
